TB-500 Frag 17-23

SKU: TB500-10

In stock

$40.00

MG:

10MG

Variant

TB-500 Frag 17-23 is a synthetic heptapeptide fragment derived from the active domain of Thymosin Beta-4 (TB-4), specifically residues 17-23. This linear sequence is studied in laboratory models for its potential roles in actin sequestration, cell migration, angiogenesis, and tissue remodeling. Characterized by its defined amino-acid composition and high stability, TB-500 Frag 17-23 is widely referenced in scientific literature for peptide structure–function analysis, cytoskeletal dynamics, and regenerative pathway research.

Researchers value TB-500 Frag 17-23 for its ability to promote localized wound healing, reduce inflammation, and support extracellular matrix organization in controlled experimental settings. Its short heptapeptide length provides enhanced tissue penetration and selectivity compared to full-length TB-4, making it an ideal tool for investigating actin-binding mechanisms and regenerative responses without systemic effects.

Ceritide Research offers TB-500 Frag 17-23 as a premium 10mg lyophilized research peptide with verified ≥99% purity confirmed by independent HPLC and mass spectrometry. Supplied in a sterile vial and ready for immediate reconstitution per your protocol, this product delivers the reliability top research labs demand.

The Purest Peptides. Period.

Research Use Only. Not for human or veterinary use.

Product Specifications

Size: 10MG
Form: Lyophilized Powder
Appearance: White to off-white powder
Weight: 0.2 lb
Dimensions: 2" x 2" x 2"

COA's & Testing

Chemical Purity: >99%
Purity & Identification Testing: HPLC & Mass Spectrometry
Net Content Weight Testing: Milligram Weight
Endotoxin Testing: < 0% Bacterial Endotoxins

Regulatory & Intended Use

Regulatory Status: Research Use Only (RUO)
Chemical Grade: Laboratory, Research, and Analytical

Research-Use Attestation

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Scientific Background

Discovery and Development
TB-500 Frag 17-23 (Ac-LKKTETQ) is a synthetic heptapeptide fragment derived from the larger 43-amino-acid protein Thymosin Beta-4 (TB-4). While TB-4 itself was first isolated in 1981 as part of the thymosin family of peptides involved in actin sequestration and cell motility, the specific 17-23 amino acid sequence was identified in the 1990s–2000s as the primary actin-binding domain responsible for promoting cell migration, angiogenesis, and tissue regeneration. Researchers synthesized this short fragment—often acetylated at the N-terminus for stability—as a focused research tool to study TB-4’s regenerative effects independently of the full-length protein.

Key Milestones in Research

1981: Discovery and initial characterization of full-length Thymosin Beta-4 in thymosin fractions.
1990s: Identification of the actin-binding domain within TB-4; early studies linking the 17-23 sequence to cell motility and wound healing.
2000s: Preclinical research highlighting the fragment’s role in angiogenesis, anti-inflammatory pathways, and extracellular matrix remodeling.
2010s–Present: Expanded in vitro and in vivo models exploring TB-500 Frag 17-23 for targeted regenerative applications, including its detection in biological samples and comparative activity versus full TB-4.

TB-500 Frag 17-23 continues to be a valuable research tool because its compact seven-amino-acid structure, high potency for actin dynamics, and selective regenerative profile allow precise investigation of wound healing, cytoskeletal organization, and tissue repair pathways—without the broader effects of the complete 43-amino-acid parent protein.

Why researchers choose Ceritide Research TB-500 Frag 17-23: High-purity 7-amino-acid actin-binding fragment ideal for regenerative, wound healing, and cytoskeletal research.

TB-500 Frag 17-23

CAS: 885340-08-9
Molecular Formula: C₃₈H₆₈N₁₀O₁₄
Molecular Weight: 889.02 g/mol
Amino Length: 7 amino acids (heptapeptide)
Classification: TB-500 is classified as a synthetic stable heptapeptide and belongs to the family of regenerative research peptides derived from Thymosin Beta-4.
Structure: Linear peptide with N-terminal acetylation
Sequence: Ac-LKKTETQ (N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-threonyl-L-glutamyl-L-threonyl-L-glutamine)
Synonyms: TB-500, TB500, TB 500, Thymosin β4 (17-23), Ac-LKKTETQ
NIH PubChem: TB-500 NIH (PubChem: CID 62707662)
NIH PubMed Article: Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential – Esposito et al., 2012

Storage Guidelines

Peptide Storage Guidelines: Best Practices for Research Stability

At Ceritide Research, we provide high-purity peptides for laboratory and scientific research. Proper storage preserves peptide integrity and supports reliable experimental results.

Storage Guidelines for Lyophilized (Powder) Peptides

Long-Term Storage: Keep at -20°C (-4°F) or lower (ideally -80°C / -112°F) for multi-year stability.
Short-Term Storage: Refrigerate at 2–8°C (36–46°F) for weeks to a few months. Minimize room temperature exposure.
Best Practices: Store in airtight vials with desiccants. Allow vials to reach room temperature in a desiccator before opening. Protect from light and moisture. Aliquot to reduce freeze-thaw cycles.

Storage Guidelines for Reconstituted Peptide Solutions

Once dissolved, peptides are less stable and should be used promptly:

Recommended Temperature: Store at 2–8°C (36–46°F) (refrigerator) for short-term use, typically up to 1–4 weeks depending on the sequence and buffer.
Longer-Term Solution Storage: Aliquot and freeze at -20°C (-4°F) or lower. Avoid storing solutions long-term when possible.
Best Practices: Use sterile techniques, bacteriostatic water or research-grade buffers, and minimize exposure to air and light. Prevent repeated freeze-thaw cycles.

For Research Use Only
All products from Ceritide Research are sold for research, laboratory, or analytical purposes only, and are not for human consumption. Our peptides are intended exclusively for in vitro scientific research and are not for human or veterinary use.

TB-500 Frag 17-23

$40.00

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Purity 99%+

All products are sold for research, laboratory, or analytical purposes only, and are not for human consumption.